Matchups › Diana › vs Lissandra

Diana vs Lissandra

DianaYOU · MID
LissandraENEMY · MID
VS
Heavily unfavoredPre-6 HardPost-6 HardTake Ignite

How to play it

Respect her gank setup
The enemy jungler is the biggest threat: her W is the gank-setup CC, so be very careful of her roaming and setups.
Trade jungler-free
Play heavy trades only when you know the jungler isn't near: baiting out her ult 1v1 is the perfect outcome.
Stay healthy early
Don't stand behind minions and keep your HP high at levels 1-2 so she can't set up a kill.
Never side lane alone in the mid game: with her setup and the jungler collapsing on you it's a death sentence.
Runes
DOMINATIONDOMINATION
Electrocute
Dark Harvest
Hail of Blades
Cheap Shot
Taste of Blood
Sudden Impact
Sixth Sense
Grisly Mementos
Deep Ward
Treasure Hunter
Relentless Hunter
Ultimate Hunter
RESOLVERESOLVE
Demolish
Font of Life
Shield Bash
Conditioning
Second Wind
Bone Plating
Overgrowth
Revitalize
Unflinching
SHARDS
Adaptive
Attack Speed
Ability Haste
Adaptive
Move Speed
Health Scaling
Health +65
Tenacity
Health Scaling
Spells
FlashFLASH
IgniteIGNITE
Items
Start
Core
16.14 Emerald+ - 53% WR - 904 games
Skill order
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WWWWW
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RRR
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Diana · Mid · Patch 26.17 · Ranked Solo · Updated Sep 5, 2026

Diana vs Lissandra in Mid lane is a hard lane on patch 26.17. The one thing to respect: the jungler is the real killer, Lissandra's W lockdown sets up the gank, so respect her setups and roams.

Diana matchup data compiled from the contributions of Diana OTPsLeague of Legends assets © Riot Games (Data Dragon).