Matchups › Cassiopeia › vs Ryze

Cassiopeia vs Ryze

CassiopeiaYOU · MID
RyzeENEMY · MID
VS
Favors youPre-6 EasyPost-6 EasyTake Teleport

How to play it

Dodge his Q
Overload is his main damage and resets off his W and E: only take trades where you can sidestep it or land a free auto.
Punish his E cooldown
His E is his combo amp; the brief moment it's on its short cooldown he's at his weakest: go in then.
Poison wins fights
You win every extended fight if you land poison: later, abuse him whenever his spells are down or out of range.
Never bunch up on the minion wave: his E spreads onto you from nearby minions.
Runes
SORCERYSORCERY
Summon Aery
Arcane Comet
Stormraider's Surge
Deathfire Touch
Axiom Arcanist
Manaflow Band
Nimbus Cloak
Transcendence
Celerity
Absolute Focus
Scorch
Waterwalking
Gathering Storm
PRECISIONPRECISION
Absorb Life
Triumph
Presence of Mind
Legend: Alacrity
Legend: Haste
Legend: Bloodline
Coup de Grace
Cut Down
Last Stand
SHARDS
Adaptive
Attack Speed
Ability Haste
Adaptive
Move Speed
Health Scaling
Health +65
Tenacity
Health Scaling
Spells
FlashFLASH
TeleportTELEPORT
Items
Start
Core
16.14 Emerald+ - 51% WR - 374 games
Skill order
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QQQQQ
WWWWW
EEEEE
RRR
MAXEEQQWW
Cassiopeia · Mid · Patch 26.17 · Ranked Solo · Updated Sep 5, 2026

Cassiopeia vs Ryze in Mid lane is a favourable lane on patch 26.17. The one thing to respect: his Q Overload is his main damage, only trade when you can dodge it.

Cassiopeia matchup data compiled from the contributions of Cassiopeia OTP mainsLeague of Legends assets © Riot Games (Data Dragon).