Matchups › Ambessa › vs Vayne

Ambessa vs Vayne

AmbessaYOU · TOP
VayneENEMY · TOP
VS
Heavily unfavoredPre-6 HardPost-6 HardTake Ignite

How to play it

Dodge her Condemn
Position so her E can't pin you to a wall: a Condemn stun under her tower is what ends you.
Go when she Q's in
Her Q toward you is your signal: go in with W-E-Q-Q out and burst her before she recovers.
Sweeper vs stat-check
Take sweeping lens and hide in bushes early to avoid her Lethal Tempo simply stat-checking you.
Never let her push you against a wall: the E Condemn stun, especially under tower, is the hit that kills you.
Runes
RESOLVERESOLVE
Grasp of the Undying
Aftershock
Guardian
Demolish
Font of Life
Shield Bash
Conditioning
Second Wind
Bone Plating
Overgrowth
Revitalize
Unflinching
INSPIRATIONINSPIRATION
Hextech Flashtraption
Magical Footwear
Cash Back
Triple Tonic
Time Warp Tonic
Biscuit Delivery
Cosmic Insight
Approach Velocity
Jack Of All Trades
SHARDS
Adaptive
Attack Speed
Ability Haste
Adaptive
Move Speed
Health Scaling
Health +65
Tenacity
Health Scaling
Spells
FlashFLASH
IgniteIGNITE
Items
Start
Core
16.14 Emerald+ - 50% WR - 540 games
Skill order
123456789101112131415161718
QQQQQ
WWWWW
EEEEE
RRR
MAXQQEEWW
Ambessa · Top · Patch 26.17 · Ranked Solo · Updated Sep 5, 2026

Ambessa vs Vayne in Top lane is a hard lane on patch 26.17. The one thing to respect: her Condemn (E), a stun into a wall, especially under her tower, kills you.

Ambessa matchup data compiled from a dedicated Ambessa OTP's matchup sheetLeague of Legends assets © Riot Games (Data Dragon).